Arenavirus
 Arenaviridae | |
|---|---|
 Lassa virus z čeledi Arenaviridae | |
| Baltimorova klasifikace virů | |
| Skupina | V (ssRNA viry s negativní polaritou) |
| Vědecká klasifikace | |
| Realm | Riboviria |
| Říše | Orthornavirae |
| Kmen | Negarnaviricota |
| Podkmen | Polyploviricotina |
| Třída | Ellioviricetes |
| Řád | Bunyavirales |
| Čeleď | Arenaviridae |
| Rod | |
| |
| Některá data mohou pocházet z datové položky. | |
Arenavirus je zastaralý rod RNA virů – dříve jediný zástupce čeledi Arenaviridae, nyní rozdělené na čtyři různé rody.[1] Jde o ssRNA obalené viry s negativní polaritou.
U lidí způsobuje horečku Lassa – závažnou hemoragickou (krvácivou) horečku. Donedávna se myslelo, že napadá jen savce – hlodavce a člověka – ale ukázalo se, že způsobuje i tzv. nemoc opilých hadů (ICV – Inclusion Body Disease),[2] která napadá především hroznýšovité hady.
Nová klasifikace ICTV již uvádí rozděleně 4 různé rody, Antennavirus, Hartmanivirus, Mammarenavirus (savčí) a Reptarenavirus (plazí).[1]
Odkazy
Reference
- ↑ a b International Committee on Taxonomy of Viruses, Virus Taxonomy: 2019 Release. Dostupné online (anglicky)
- ↑ Virus „opilých“ hadů [online]. Český rozhlas Leonardo, 2012-08-14 [cit. 2012-08-14]. Dostupné online.
Externí odkazy
Obrázky, zvuky či videa k tématu Arenavirus na Wikimedia Commons - Schéma viru na webu Viralzone (anglicky)
- TĚŠÍKOVÁ, Jana. Arenaviry a hantaviry afrických drobných savců [online]. Masarykova universita, 2012-05-11 [cit. 2012-08-14]. Bakalářská práce. Dostupné online.
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ID#: 8699 Description: This highly magnified transmission electron micrograph (TEM) depicted some of the ultrastructural details of a number of Lassa virus virions adjacent to some cell debris. The virus, a member of the virus family Arenaviridae, is a single-stranded RNA virus, and is zoonotic, or animal-borne that can be transmitted to humans. The illness, which occurs in West Africa, was discovered in 1969 when two missionary nurses died in Nigeria, West Africa. In areas of Africa where the disease is endemic (that is, constantly present), Lassa fever is a significant cause of morbidity and mortality. While Lassa fever is mild or has no observable symptoms in about 80% of people infected with the virus, the remaining 20% have a severe multisystem disease. Lassa fever is also associated with occasional epidemics, during which the case-fatality rate can reach 50%.
Signs and symptoms of Lassa fever typically occur 1-3 weeks after the patient comes into contact with the virus. These include fever, retrosternal pain (pain behind the chest wall), sore throat, back pain, cough, abdominal pain, vomiting, diarrhea, conjunctivitis, facial swelling, proteinuria (protein in the urine), and mucosal bleeding. Neurological problems have also been described, including hearing loss, tremors, and encephalitis. Because the symptoms of Lassa fever are so varied and nonspecific, clinical diagnosis is often difficult.
Approximately 15%-20% of patients hospitalized for Lassa fever die from the illness. However, overall only about 1% of infections with Lassa virus result in death. The death rates are particularly high for women in the third trimester of pregnancy, and for fetuses, about 95% of which die in the uterus of infected pregnant mothers.